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Feelings of worthlessness are commonly associated with depression, as this mental health condition often involves a pervasive negative self-image, self-criticism, and a sense of hopelessness. Individuals experiencing depression may ruminate on personal failures or perceived shortcomings, leading to a profound belief that they are unworthy or inadequate. This self-perception is a significant aspect of the disorder and can contribute to the overall severity of depressive symptoms.

In the context of other mental health conditions listed, while individuals experiencing stress or anxiety may experience negative thoughts, they do not typically involve the same persistent feelings of worthlessness found in depression. Attention Deficit Hyperactivity Disorder (ADHD) may lead to self-esteem issues due to challenges in focus or behavior, but it does not predominantly manifest as a feeling of worthlessness in the same way that depression does. Therefore, the presence of worthlessness is closely aligned with the symptoms of depression.